PXD060426 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Top-down proteomics study of aging and sexual dimorphism of zebrafish brains |
| Description | Here, we present the first example of studying the aging and sexual dimorphism of brains using the zebrafish (Danio rerio) model organism by mass spectrometry (MS)-based quantitative top-down proteomics (TDP). We measured the proteoforms in male and female zebrafish brains across three ages (6, 16, and 24 months) using capillary zone electrophoresis-tandem MS (CZE-MS/MS). Our research indicates that male and female zebrafish exhibit significant differences in the abundance of important proteoforms. Significant age-related changes were observed in proteoforms associated with critical neurological processes, including neurofilament assembly, dopaminergic neuron differentiation, and synaptic vesicle priming. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-12 |
| AnnouncementXML | Submission_2026-01-11_16:51:44.248.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Liangliang Sun |
| SpeciesList | scientific name: Danio rerio (Zebrafish) (Brachydanio rerio); NCBI TaxID: NEWT:7955; |
| ModificationList | phosphorylated residue; acetylated residue; monohydroxylated residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-02-03 09:11:58 | ID requested | |
| ⏵ 1 | 2026-01-11 16:51:45 | announced | |
Publication List
| 10.1002/jms.70009; |
| Askarani MF, Poulos W, Dashtaki MR, Sadeghi SA, Cibelli JB, Fang F, Sun L, Top-Down Proteomics Study of Aging and Sexual Dimorphism of Zebrafish Brains. J Mass Spectrom, 61(1):e70009(2026) [pubmed] |
Keyword List
| submitter keyword: Central nervous system aging Proteoform identification Zebrafish |
Contact List
| Liangliang Sun |
|---|
| contact affiliation | Department of Chemistry, Michigan State University, 578 S Shaw Lane, East Lansing, Michigan 48824, USA |
| contact email | lsun@chemistry.msu.edu |
| lab head | |
| Liangliang Sun |
|---|
| contact affiliation | Michigan State University |
| contact email | lsun@chemistry.msu.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD060426 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD060426
- Label: PRIDE project
- Name: Top-down proteomics study of aging and sexual dimorphism of zebrafish brains
