PXD060421-1

PXD060421 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	N-terminomics on WT and CASP2 KO mouse hearts
Description	To identify putative substrates processed by Caspase-2 in response to PIDDosome activation in cardiomyocytes, we performed N-terminomics by TMT10-TAILS on P7 hearts isolated from XMLC2-Casp2fl/fl and XMLC2+Casp2fl/fl mice.
HostingRepository	PRIDE
AnnounceDate	2026-01-15
AnnouncementXML	Submission_2026-01-15_00:49:23.926.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Piero Giansanti
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Eclipse

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-03 04:59:30	ID requested
⏵ 1	2026-01-15 00:49:25	announced

Publication List

10.1038/s41418-025-01645-x;
Leone M, Kinz N, Eichin F, Obwegs D, Sladky VC, Braun VZ, Hirschberger R, Rizzotto D, Englmaier L, Manzl C, Moos K, Mergner J, Giansanti P, Martinez-Garcia N, Marques MM, Jacotot ED, Eblahed L, Yousif R, Wright MK, Dawood D, Maupome LS, Savko C, Boerries M, Sussman MA, Villunger A, The PIDDosome controls cardiomyocyte polyploidization during postnatal heart development. Cell Death Differ, ():(2026) [pubmed]

10.1038/s41418-025-01645-x;

Leone M, Kinz N, Eichin F, Obwegs D, Sladky VC, Braun VZ, Hirschberger R, Rizzotto D, Englmaier L, Manzl C, Moos K, Mergner J, Giansanti P, Martinez-Garcia N, Marques MM, Jacotot ED, Eblahed L, Yousif R, Wright MK, Dawood D, Maupome LS, Savko C, Boerries M, Sussman MA, Villunger A, The PIDDosome controls cardiomyocyte polyploidization during postnatal heart development. Cell Death Differ, ():(2026) [pubmed]

Keyword List

submitter keyword: TMT-TAILS, caspase 2, heart developement, n-terminomics

submitter keyword: TMT-TAILS, caspase 2, heart developement, n-terminomics

Contact List

Piero Giansanti
contact affiliation	Bavarian Center for Biomolecular Mass Spectrometry at Klinikum Rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany
contact email	piero.giansanti@tum.de
lab head
Piero Giansanti
contact affiliation	Technical University of Munich
contact email	piero.giansanti@tum.de
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD060421
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD060421

PRIDE project URI

Repository Record List

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