PXD060396 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Knockdown of endocytosis-related proteins in Trypanosoma brucei (TbVPS23) |
| Description | TbVPS23 is part of the ESCRT-I (endosome-sorting complex required for transport-I) complex in Trypanosoma brucei. Moreover, TbTOM1 is an ortholog of human TOM1, which was identified in Trypanosomes by bioinformatic approaches, and is potentially implicated in endocytosis. We wanted to further investigate TbVSP23 and TbTOM1 functions. Using a gene silencing (RNAi) approach we wanted to gain insights on possible effects on vesicle sorting and/or other endocytosis-related activities. Controls from 2T1 cells (parental cells) are included in this set. Please note that this data set is paired to PXD060385, which includes data of TbTOM1 RNAi. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-24 |
| AnnouncementXML | Submission_2026-08-24_06:16:20.506.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | NORMA PADILLA MEJIA |
| SpeciesList | scientific name: Trypanosoma brucei; NCBI TaxID: NEWT:5691; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF; LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-01-31 07:29:04 | ID requested | |
| ⏵ 1 | 2026-08-24 06:16:21 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Trypanosoma, TOM1, VPS23, gene silencing, endosome-sorting complex required for transport, endocytosis, RNAi |
Contact List
| Prof. Mark C Field |
|---|
| contact affiliation | Biological Chemistry and Drug Discovery Unit, School of Life Sciences, University of Dundee |
| contact email | mfield@mac.com |
| lab head | |
| NORMA PADILLA MEJIA |
|---|
| contact affiliation | University of Dundee |
| contact email | nepadillam@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD060396 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD060396
- Label: PRIDE project
- Name: Knockdown of endocytosis-related proteins in Trypanosoma brucei (TbVPS23)
