PXD060380-1
PXD060380 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation |
| Description | In targeted protein degradation (TPD) a protein of interest is degraded by chemically induced proximity to an E3 ubiquitin ligase. One limitation of using TPD therapeutically is that most E3 ligases have broad tissue expression, which can contribute to toxicity via target degradation in healthy cells. Many pathogenic and oncogenic viruses encode E3 ligases (vE3s), which de facto have strictly limited expression to diseased cells. Here, we provide proof-of-concept for Viral E3 Pan-Essential Removing Targeting Chimeras (VIPER-TACs) that are bi-functional molecules that utilize viral E3 ubiquitin ligases to selectively degrade pan-essential proteins and eliminate diseased cells. We find that the human papillomavirus (HPV) ligase E6 can degrade the SARS1 pan-essential target protein in a model of HPV-positive cervical cancer to selectively kill E6 expressing cancer cells. Thus, VIPER-TACs have the capacity to dramatically increase the therapeutic window, alleviate toxicity concerns, and ultimately expand the potential target space for TPD. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-01-30 |
| AnnouncementXML | Submission_2025-01-30_13:58:49.494.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jeff Liu |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-01-30 13:27:46 | ID requested | |
| ⏵ 1 | 2025-01-30 13:58:49 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: targeted protein degradation, viral E3 ligase, DatasetType:Proteomics |
Contact List
| Patrick Ryan Potts | |
|---|---|
| contact affiliation | Amgen Research |
| contact email | ryan.potts@amgen.com |
| lab head | |
| Jeff Liu | |
| contact affiliation | Amgen |
| contact email | jliu19@amgen.com |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v09/MSV000097003/ |
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