PXD060361-1

PXD060361 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Protecomics analysis of toxin-antitoxin system HigBA mutant in P.aeruginosa
Description	Pseudomonas aeruginosa kill the host Drosophila melanogasger very rapidly due to bacteria fitness in vivo. However, mutant of antitoxin HigA has impaired virulence accompanying with loss of fitness. We suppose the free toxin HigB in higA mutant inhibits some proteins production as to be an RNase. To explore the mechanism of antitoxin HigA leading to bacteria fitness in Drosophila, we performed proteomics to analyze the differential proteins in higA mutant in vitro.
HostingRepository	PRIDE
AnnounceDate	2025-09-21
AnnouncementXML	Submission_2025-09-20_21:04:50.844.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jing Chen
SpeciesList	scientific name: Pseudomonas aeruginosa PAO1; NCBI TaxID: 208964;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-30 04:23:35	ID requested
⏵ 1	2025-09-20 21:04:51	announced

Publication List

10.1038/S41467-025-64071-0;

10.1038/S41467-025-64071-0;

Keyword List

submitter keyword: cAMP,Vfr,Pseudomonas aeruginosa, Type IV pili,toxin-antitoxin HigBA

submitter keyword: cAMP,Vfr,Pseudomonas aeruginosa, Type IV pili,toxin-antitoxin HigBA

Contact List

Jing Chen,Guiying Lin, Kaiyu Ma, Yunxue Guo, Xiaoxue Wang, Zi Li, Dominique Ferrandon
contact affiliation	Guangzhou Medical University
contact email	2405086799@qq.com
lab head
Jing Chen
contact affiliation	Guangzhou Medical University
contact email	2405086799@qq.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD060361
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD060361

PRIDE project URI

Repository Record List

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