PXD060359-1

PXD060359 is an original dataset announced via ProteomeXchange.

Title	ID8 cells manifest phenotypic plasticity and molecular heterogeneity of high-grade serous ovarian cancer in response to the local tissue niche ID8 cells manifest phenotypic plasticity and molecular heterogeneity of high-grade serous ovarian cancer in response to the local tissue niche
Description	Spontaneously transformed mouse ovarian surface epithelial cell line ID8 generates a syngeneic mouse model, frequently used in pre-clinical evaluation. Towards a precise, subtype-specific perspective of such applications, we thought it pertinent to study its stratification into a specific molecular subtype, which would provide an accurate setting for interpretation of experimental data. Stratification of ID8 model was achieved through phenotypic, histopathological, and molecular assessment of ID8 cells grown in vitro, its primary xenografts and metastases. TME investigation of primary and metastatic tumors revealed contrasting immune populations.
HostingRepository	PRIDE
AnnounceDate	2025-10-13
AnnouncementXML	Submission_2025-10-12_16:27:26.612.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ritika Gupta
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-30 03:50:17	ID requested
⏵ 1	2025-10-12 16:27:27	announced

Gupta R, Shravan S, Agwane SB, Bankar RM, Bapat SA, ID8 cells manifest phenotypic plasticity and molecular heterogeneity of high-grade serous ovarian cancer in response to the local tissue niche. Sci Rep, 15(1):34626(2025) [pubmed]

10.1038/s41598-025-18264-8;

ProteomeXchange project tag: Cancer (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: Phenotypic plasticity,D8, ascites.

Sharmila Bapat
contact affiliation	National Centre for Cell Science, Pune
contact email	sabapat@nccs.res.in
lab head
Ritika Gupta
contact affiliation	National Centre for Cell Science Pune
contact email	ritika.gupta222@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD060359

PRIDE project URI

• PRIDE
  1. PXD060359
     1. Label: PRIDE project
     2. Name: ID8 cells manifest phenotypic plasticity and molecular heterogeneity of high-grade serous ovarian cancer in response to the local tissue niche ID8 cells manifest phenotypic plasticity and molecular heterogeneity of high-grade serous ovarian cancer in response to the local tissue niche