PXD060341-1

PXD060341 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Pfs230 and Pfs48/45 complex SDA XL-MS
Description	Asexual P. falciparum parasite cultures were maintained, gametocytes harvested and pellets lysed prior to chromatography procedures including size exclusion. Chemical cross-linking MS (XL-MS) analysis using SDA and UV exposure was performed followed by SDS-PAGE, gel bands excised and subjected to trypsin digestion and MS analysis.
HostingRepository	jPOST
AnnounceDate	2026-01-27
AnnouncementXML	Submission_2026-01-26_15:14:35.512.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Laura Dagley
SpeciesList	scientific name: Plasmodium (Plasmodium); NCBI TaxID: 418103;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; unknown modification; unknown modification
Instrument	Orbitrap Eclipse

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-29 15:21:15	ID requested
⏵ 1	2026-01-26 15:14:36	announced

Publication List

Dietrich MH, Chmielewski J, Chan LJ, Tan LL, Adair A, Lyons FMT, Gabriela M, Lopaticki S, Dite TA, Dagley LF, Pazzagli L, Gupta P, Kamil M, Vaughan AM, Rojrung R, Abraham A, Mazhari R, Longley RJ, Zeglinski K, Gouil Q, Mueller I, Fabb SA, Shandre-Mugan R, Pouton CW, Glukhova A, Shakeel S, Tham WH, Pfs230 and Pfs48/45 fertilization complex. Science, 389(6765):eady0241(2025) [pubmed]

Dietrich MH, Chmielewski J, Chan LJ, Tan LL, Adair A, Lyons FMT, Gabriela M, Lopaticki S, Dite TA, Dagley LF, Pazzagli L, Gupta P, Kamil M, Vaughan AM, Rojrung R, Abraham A, Mazhari R, Longley RJ, Zeglinski K, Gouil Q, Mueller I, Fabb SA, Shandre-Mugan R, Pouton CW, Glukhova A, Shakeel S, Tham WH, Pfs230 and Pfs48/45 fertilization complex. Science, 389(6765):eady0241(2025) [pubmed]

Keyword List

submitter keyword: malaria, vaccine, transmission blocking, Pfs230, Pfs48/45, fertilization, cryo-EM, nanobody, mRNA-LNP, Plasmodium falciparum

submitter keyword: malaria, vaccine, transmission blocking, Pfs230, Pfs48/45, fertilization, cryo-EM, nanobody, mRNA-LNP, Plasmodium falciparum

Contact List

Wai-Hong Tham
lab head
Laura Dagley
contact affiliation	WEHI
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003585/