PXD060315 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Liver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma |
| Description | Paraoxonase-1 (PON1) is specifically expressed in the liver and has crucial effects on various liver diseases. The functions and mechanisms underlying of PON1 in hepatocellular carcinoma (HCC) remain obscure. Here, we show that PON1 acts as a metabolic regulator to mitigate regulatory T (Treg) cell-induced immunosuppression and HCC progression. Mechanistically, PON1 crippled lactic acid generation via recruiting Von Hippel-Lindau protein (VHL) to ubiquitinate Hypoxia-inducible factor alpha (HIF-1α), thereby reducing Treg cell frequency in HCC. In clinical settings, high PON1 expression correlated with better prognosis in HCC patients. Recombinant PON1 protein (rPON1) exhibited remarkable potency in impeding tumor growth, meanwhile, enhancing PON1 expression by Quercetin sensitized HCC to anti-programmed death-1(PD-1) therapy. Our findings elucidate a novel role of PON1 in orchestrating lactic acid production to relieve immunosuppression and suppress HCC, which paves the way for therapeutic intervention of HCC by targeting PON1. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-22 |
| AnnouncementXML | Submission_2025-12-21_16:27:23.863.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Huanchen Shi |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-01-29 06:22:31 | ID requested | |
| ⏵ 1 | 2025-12-21 16:27:24 | announced | |
Publication List
| Lu Z, Shi H, Gao R, Zhong C, Zhang W, Zhu J, Huang J, Liu R, Xing Y, Chu Y, Sun H, Shi G, Ke A, Zhou J, Cai J, Fan J, Gao P, Huang C, Liver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma. Nat Commun, 16(1):11034(2025) [pubmed] |
| 10.1038/s41467-025-66168-y; |
Keyword List
| submitter keyword: liver cancer,PON-1 |
Contact List
| Cheng Huang |
|---|
| contact affiliation | Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China |
| contact email | huang.cheng@zs-hospital.sh.cn |
| lab head | |
| Huanchen Shi |
|---|
| contact affiliation | Fudan University |
| contact email | shihuanchen1126@163.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD060315 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD060315
- Label: PRIDE project
- Name: Liver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma
