PXD060035-1

PXD060035 is an original dataset announced via ProteomeXchange.

Title	Large-scale Proteomics Profiling of Peripheral Blood of DM1 patients identifies biomarkers for disease severity and physical activity - Validation cohort
Description	Myotonic Dystrophy type 1 (DM1) is a progressive multisystem disease with large heterogeneity in disease onset, symptom development, progression rates and severity. This poses significant challenges to the design of clinical trials. To overcome some of these challenges, this study aims to identify protein biomarkers in serum that can serve as measures of therapy response. Biomarker discovery was performed in serum samples of DM1 patients in the OPTIMISTIC trial, which is deposited elsewhere. The dataset in this project comprises data generated on the Canadian cohort of DM1 patients which was used as external validation cohort.
HostingRepository	PRIDE
AnnounceDate	2026-01-20
AnnouncementXML	Submission_2026-01-20_11:42:09.233.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jolein Gloerich
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-21 15:38:23	ID requested
⏵ 1	2026-01-20 11:42:10	announced

10.1177/22143602251410443;

van As D, Claeys T, Salz R, Haver DV, Dufour S, Deelen AV, Gloerich J, Gabriels R, Volders PJ, Dobelmann V, Gangfuss A, Ruck T, Gourdon G, Duchesne E, Gagnon C, Roos A, Gool AV, Impens F, Martens L, Lochm, ü, ller H, Schoser B, Bassez G, van Engelen BG, 't Hoen PA, Large-scale proteomics profiling of peripheral blood of DM1 patients identifies biomarkers for disease severity and functional capacity. J Neuromuscul Dis, ():22143602251410443(2026) [pubmed]

submitter keyword: None

Jolein Gloerich
contact affiliation	Department of Human Genetics, Radboud University Medical Center Nijmegen
contact email	jolein.gloerich@radboudumc.nl
lab head
Jolein Gloerich
contact affiliation	Department of Human Genetics, Radboud University Medical Center Nijmegen
contact email	jolein.gloerich@radboudumc.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD060035

PRIDE project URI

• PRIDE
  1. PXD060035
     1. Label: PRIDE project
     2. Name: Large-scale Proteomics Profiling of Peripheral Blood of DM1 patients identifies biomarkers for disease severity and physical activity - Validation cohort