PXD060032-1

PXD060032 is an original dataset announced via ProteomeXchange.

Title	Mouse islet ATG7 beta-cell knockout LC-MS/MS
Description	We knocked out the critical autophagy enzyme, ATG7, in the β-cells of mice (ATG7Δβ-cell) then monitored blood glucose to assess the phenotype induced by this KO model. We found that all ATG7Δβ-cell mice developed diabetes between 11-15 weeks of age. We isolated islets from ATG7Δβ-cell and littermate control mice several weeks prior to diabetes development (7-10 weeks of age) and performed bulk islet proteomics. The purpose of this experiment was to understand the islet biological process pathways altered by dysfunctional β-cell autophagy in the ATG7Δβ-cell model.
HostingRepository	PRIDE
AnnounceDate	2025-01-22
AnnouncementXML	Submission_2025-01-22_07:21:09.799.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Matt Austin
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; acetylated residue; monohydroxylated residue; deamidated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-21 13:42:57	ID requested
⏵ 1	2025-01-22 07:21:10	announced

10.3389/FIMMU.2025.1504583;

submitter keyword: mouse islet, ATG7 beta-cell knockout, LC-MS/MS

Amelia K. Linnemann
contact affiliation	Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, United States
contact email	aklinnem@iu.edu
lab head
Matt Austin
contact affiliation	Indiana University School of Medicine
contact email	mattaust@iu.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD060032
     1. Label: PRIDE project
     2. Name: Mouse islet ATG7 beta-cell knockout LC-MS/MS