PXD059993 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Multiomics reveals placental defect underlying preeclampsia |
| Description | Preeclampsia is a serious pregnancy-induced disorder unique to humans affecting 4.6% of pregnancies worldwide. Advances in the detection, prevention and treatment of preeclampsia have been poor due to our inadequate understanding of its pathogenesis. Here, we perform a multiomics study on early pregnancy placental biopsies (chorionic villus samples) from pregnancies that developed preterm and term preeclampsia compared to normotensive controls. Using an integrative statistical approach we discovered preterm preeclampsia was highly associated with lipoprotein metabolism whereas term preeclampsia was associated with inflammatory pathways and notch signaling. Melanophilin was identified as significantly reduced in early pregnancy placenta from term preeclampsia. Loss of melanophilin was required for syncytialization but excess loss disrupts syncytiotrophoblast function driving the production of antiangiogenic factors known to drive preeclampsia. Our study challenges the dogma that term preeclampsia is not associated with early placental pregnancy dysfunction and provides critical insight into the early pregnancy dysfunction underlying preeclampsia, opening up new avenues for predictive biomarker and preventative treatment discovery. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-10 |
| AnnouncementXML | Submission_2026-06-09_20:47:33.141.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yimiao Yu |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Ascend; LTQ Orbitrap Elite |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-01-20 18:59:56 | ID requested | |
| ⏵ 1 | 2026-06-09 20:47:34 | announced | |
Publication List
| Menkhorst E, Yang G, Yu Y, Santos LL, Zhou W, Syngelaki A, Varshney S, Williamson NA, Koga K, Rolnik DL, da Silva Costa F, Nicolaides K, L, ê, Cao KA, Dimitriadis E, Multi-Omics Reveals Early Pregnancy Placental Dysfunction Associated With Preterm and Term Preeclampsia. MedComm (2020), 7(6):e70784(2026) [pubmed] |
| 10.1002/mco2.70784; |
Keyword List
| submitter keyword: multiomics,preeclampsia, placental defects, placenta, CVS |
Contact List
| Eva Dimitriadis |
|---|
| contact affiliation | Royal Women's Hospital |
| contact email | evdokia.dimitriadis@unimelb.edu.au |
| lab head | |
| Yimiao Yu |
|---|
| contact affiliation | Royal Women's Hospital |
| contact email | yimiaoy1@student.unimelb.edu.au |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD059993 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD059993
- Label: PRIDE project
- Name: Multiomics reveals placental defect underlying preeclampsia
