PXD059984 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Probing downstream effects of ALK and ROS1 fusion oncogenes in Glioma using proteomics |
| Description | To identify targets of aberrantly expressed RTK-fusion oncogenes, serine/threonine and tyrosine phosphorylation signatures in transgenic cells lines expressing different RTK-fusion oncogenes were compared with their respective kinasedead mutant counterparts. Comparing the differentially phosphorylated proteins between the different RTK fusions were used to identify commonly deregulated pathways as well as pathways specifically targeted by individual RTK-fusions. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-22 |
| AnnouncementXML | Submission_2026-01-22_08:54:46.922.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ana Sofia Guerreiro Stücklin |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-01-20 09:08:09 | ID requested | |
| ⏵ 1 | 2026-01-22 08:54:47 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: ALK, AP-MS, ROS1, immortalized normal human astrocytes, phosphoprotoemics, RTK-fusion oncoproteins |
Contact List
| Ana Sofia |
|---|
| contact affiliation | Department of Oncology and Children's Research Center, University Children's Hospital of Zurich, Zurich, Switzerland |
| contact email | Ana.Stuecklin@kispi.uzh.ch |
| lab head | |
| Ana Sofia Guerreiro Stücklin |
|---|
| contact affiliation | Translational Brain Tumor Research, Division of Oncology, University Children's Hospital Zurich, Zurich, Switzerland |
| contact email | ana.stuecklin@kispi.uzh.ch |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD059984 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD059984
- Label: PRIDE project
- Name: Probing downstream effects of ALK and ROS1 fusion oncogenes in Glioma using proteomics
