PXD059954-2
PXD059954 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The analysis of GSDME-NT binding proteins in the presence or absence of methionine |
| Description | Our study identify that methionine inhibits N-terminus of GSDME (GSDME-NT) -mediated pyroptosis by dampening its endocytotic degradation. Thus，the binding proteins of GSDME-NT are detected in the presence or absence of Methionine for futher exploration。 |
| HostingRepository | iProX |
| AnnounceDate | 2025-01-19 |
| AnnouncementXML | Submission_2025-04-24_19:07:26.887.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jiawei Wu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-01-19 23:13:07 | ID requested | |
| 1 | 2025-01-19 23:15:21 | announced | |
| ⏵ 2 | 2025-04-24 19:07:30 | announced | 2025-04-25: Add Publication. |
Publication List
| Wu J, Ding C, Zhang C, Xu Z, Deng Z, Wei H, He T, Long L, Tang L, Ma J, Liang X, Methionine metabolite spermidine inhibits tumor pyroptosis by enhancing MYO6-mediated endocytosis. Nat Commun, 16(1):2184(2025) [pubmed] |
Keyword List
| submitter keyword: Human, HONE1 cells, Mass spectrometry |
Contact List
| Jun Ma | |
|---|---|
| contact affiliation | Sun Yat-sen University Cancer Center |
| contact email | majun2@mail.sysu.edu.cn |
| lab head | |
| Jiawei Wu | |
| contact affiliation | Sun Yat-sen University Cancer Center |
| contact email | gary1210@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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