PXD059919 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic analysis of a molecular glue to redirect lysine acetyltransferase for selective induction of cell death |
| Description | Lysine acetyltransferases (KATs) such as p300 and CBP regulate gene networks in healthy and malignant cells by scaffolding transcriptional machinery and by acetylating chromatin and transcription factors (TFs). In certain cancers including diffuse large B cell lymphomas, they contribute to tumor suppression and are therapeutic vulnerabilities when deregulated. Inhibitors and degraders of KATs are limited by potential toxicity associated with targeting these essential proteins. We introduce KAT-TCIPs (lysine acetyltransferase transcriptional/epigenetic chemical inducers of proximity), bivalent molecules that redirect the KAT and co-activating activity of p300 and CBP towards programmed cell death signaling repressed by the oncogenic TF BCL6. The lead KAT-TCIP molecule kills lymphoma cells at ~0.8 nM by redistributing chromatin acetylation, activating the pro-apoptotic protein PUMA, and repressing MYC. Analysis of the ternary co-crystal structure containing p300 and BCL6 reveals fortuitous interactions that drive the potency and specificity of KAT-TCIPs and sets a precedent for KAT-targeting induced proximity therapeutics. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-22 |
| AnnouncementXML | Submission_2026-07-22_13:26:31.192.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Brendan Dwyer |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | timsTOF HT |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-01-17 06:27:30 | ID requested | |
| ⏵ 1 | 2026-07-22 13:26:31 | announced | |
Publication List
Keyword List
| submitter keyword: Human, cancer, transcription, induced proximity, molecular glues |
Contact List
| Nathanael Gray |
|---|
| contact affiliation | Professor of Chemical and Systems Biology at Stanford, USA |
| contact email | nsgray01@stanford.edu |
| lab head | |
| Brendan Dwyer |
|---|
| contact affiliation | Stanford University |
| contact email | dwyermrbrendan@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD059919 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD059919
- Label: PRIDE project
- Name: Proteomic analysis of a molecular glue to redirect lysine acetyltransferase for selective induction of cell death
