PXD059885 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | SILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy |
| Description | Post-hepatectomy liver failure (PHLF) remains a significant risk for patients undergoing partial hepatectomy (PHx). Reliable prognostic markers and treatments to enhance liver regeneration are lacking. Plasma nanoparticles, including lipoproteins, exosomes, and extracellular vesicles (EVs), can reflect systemic and tissue-wide proteostasis and stress, potentially aiding liver regeneration. Our study included nine patients with hepatocellular carcinoma (HCC) undergoing PHx. Patient plasma was collected before PHx as well as 1 and 5 days after and the EV-protein repertoire was analysed by quantitative mass spectrometry using a super-SILAC mix prepared from primary and cancer cell lines. This longitudinal proteomic analysis of the EVs circulating in the plasma of human patients undergoing PHx uncovers proteomic signatures associated with PHLF, which reflect dying hepatocytes and endothelial cells and were already present before PHx. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-08-11 |
| AnnouncementXML | Submission_2025-08-11_09:01:48.519.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD059885 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Ulrike Resch |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | 6x(13)C; 6x(13)C; monohydroxylated residue; acetylated residue |
| Instrument | LTQ Orbitrap Velos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-01-16 10:09:01 | ID requested | |
| ⏵ 1 | 2025-08-11 09:01:49 | announced | |
Publication List
| 10.3390/ijms251910685; |
| Resch U, Hackl H, Pereyra D, Santol J, Brunnthaler L, Probst J, Jankoschek AS, Aiad M, Nolte H, Krueger M, Starlinger P, Assinger A, SILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy. Int J Mol Sci, 25(19):(2024) [pubmed] |
| 10.6019/PXD059885; |
Keyword List
| submitter keyword: Plasma extracellular vesicles,Post-hepatectomy liver failure, Proteomics |
Contact List
| DI Dr. Ulrike Resch |
|---|
| contact affiliation | Department of Vascular Biology and Thrombosis Research, Centre of Physiology and Pharmacology, Medical University of Vienna, Schwarzspanierstrasse 17, A-1090 Vienna, Austria |
| contact email | ulrike.resch@meduniwien.ac.at |
| lab head | |
| Ulrike Resch |
|---|
| contact affiliation | Medical University of Vienna, Deptartment of Vascular Biology and Thrombosis Research |
| contact email | ulrike.resch@meduniwien.ac.at |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD059885 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD059885
- Label: PRIDE project
- Name: SILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy
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