PXD059855-1

PXD059855 is an original dataset announced via ProteomeXchange.

Title	Identification of acetylated proteins in the hearts of mice fed a ketogenic diet
Description	Diets influence metabolism and susceptibility to disease. We have previously demonstrated that a ketogenic diet alleviates cardiac pathology, with its cardioprotective effects linked to increased lysine acetylation in the heart. To identify acetylated proteins associated with this diet, we conducted a proteomic analysis using liquid chromatography-tandem mass spectrometry in the hearts of mice fed either a ketogenic diet or a normal chow diet under hypertension. We identified 966 acetylated peptides corresponding to 320 acetylated proteins in the hearts of mice fed a normal chow diet (group A), while 1597 acetylated peptides corresponding to 425 acetylated proteins were identified in the hearts of mice fed a ketogenic diet (group M).
HostingRepository	PRIDE
AnnounceDate	2025-11-03
AnnouncementXML	Submission_2025-11-02_16:21:07.300.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD059855
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Michinari Nakamura
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	acetylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-15 22:15:42	ID requested
⏵ 1	2025-11-02 16:21:08	announced

10.6019/PXD059855;

10.1016/j.molmet.2025.102239;

Keller MA, Ivessa A, Liu T, Li H, Romanienko PJ, Nakamura M, KAT6A acetylation regulates AMPK function and hypertrophic remodeling in the heart. Mol Metab, 101():102239(2025) [pubmed]

submitter keyword: Heart, acetylation, ketogenic diet, hypertension

Michinari Nakamura
contact affiliation	Department of Cell Biology and Molecular Medicine Nakamura Lab Rutgers New Jersey Medical School Rutgers Biomedical and Health Sciences Rutgers The State University of New Jersey
contact email	nakamumi@njms.rutgers.edu
lab head
Michinari Nakamura
contact affiliation	Rutgers
contact email	nakamumi@njms.rutgers.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD059855
     1. Label: PRIDE project
     2. Name: Identification of acetylated proteins in the hearts of mice fed a ketogenic diet