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PXD059852-1

PXD059852 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	The O-GlcNAc modification of PRRC2C at S2238 promotes SG formation and nasopharyngeal carcinoma metastasis
Description	Metastasis is the leading cause of death in nasopharyngeal carcinoma (NPC), with its precise mechanism still unclear. Here we constructed high metastatic (HM) and low metastatic (LM) sublines of NPC cells via the Transwell system to research the metabolic alterations that occur during NPC metastasis. The results of metabolomics and proteomics propose that under the metabolic stress, enhanced UDP-GlcNAc promotes the O-GlcNAc modification of PRRC2C, which is a marker of Stress granules (SGs), and favor SG formation. Meanwhile, the enrichment of SG lead to alterations in mitochondrial dynamics. Mechanistically, the SG core protein NUFIP2 supressed the mTOR activity and enhanced lipophagy, as a result, reduced mitochondrial lipotoxicity and enhanced mitochondrial fission were observed in HM cells to maintain mitochondrial homeostasis. In the nude mice in situ transfer model, the use of EGCG could revise the metastatic potential of HM cells via the inhibition of SGs, thereby providing a feasible treatment strategy for patients with metastatic NPC.
HostingRepository	iProX
AnnounceDate	2025-01-15
AnnouncementXML	Submission_2025-01-15_22:05:38.355.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Meiding Shu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-15 22:05:19	ID requested
⏵ 1	2025-01-15 22:05:38	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: NPC, OGT, SG

Contact List

Meiding Shu
contact affiliation	Nantong University
contact email	15962997817@163.com
lab head
Meiding Shu
contact affiliation	Nantong University
contact email	15962997817@163.com
dataset submitter

Full Dataset Link List

iProX dataset URI