PXD059844 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic profiling of FBXO11 protein complexes |
| Description | FBXO11, a member of the F-box protein family, plays a critical role in cellular processes such as protein degradation, cell cycle regulation, and signaling pathways by serving as a substrate recognition component of the SKP1-Cullin-F-box (SCF) ubiquitin ligase complex. Dysregulation of FBXO11 has been implicated in various diseases, including cancer and developmental disorders, yet its full spectrum of interactions and functional roles remains poorly understood. This project aims to perform a comprehensive proteomic profiling of FBXO11-associated protein complexes to uncover its interaction network and better understand its biological functions. Using advanced mass spectrometry-based proteomics, we will identify and characterize the proteins that interact with FBXO11 under different cellular conditions. Additionally, bioinformatics tools will be employed to analyze the identified interactome and explore their functional enrichment in specific pathways and biological processes. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-14 |
| AnnouncementXML | Submission_2025-11-14_08:13:11.397.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zuo-Fei Yuan |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-01-15 17:25:05 | ID requested | |
| ⏵ 1 | 2025-11-14 08:13:11 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: proteomics, mass spectrometry, FBXO11 |
Contact List
| Anthony A High |
|---|
| contact affiliation | Center for Proteomics & Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| contact email | anthony.high@stjude.org |
| lab head | |
| Zuo-Fei Yuan |
|---|
| contact affiliation | St. Jude Children's Research Hospital |
| contact email | zuo-fei.yuan@stjude.org |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD059844 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD059844
- Label: PRIDE project
- Name: Proteomic profiling of FBXO11 protein complexes
