PXD059801-1
PXD059801 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The serum proteomics tracking of HBsAg low-level nucleoside analogues treatment of chronic hepatitis B combined with Pegylated Interferon therapy |
| Description | Chronic hepatitis B (CHB) remains a major public health problem worldwide. Combined use of nucleoside analogues (NAs) and polyethylene glycolated interferon (PEG-IFNα) can rapidly reduce hepatitis B surface antigen (HBsAg) levels and lead to clinical cure in some advantaged populations. However, the specific molecular mechanisms by which NAs in combination with interferon therapy achieve rapid HBsAg reduction are unknown. To investigate the biomolecular differences associated with combination therapy, we analysed serum protein mass spectra from 25 patients with chronic hepatitis B who experienced a rapid reduction in HBsAg levels after combination therapy. Analyses were performed using data-independent acquisition (DIA)-based liquid chromatography-mass spectrometry before treatment, at week 12 of treatment, and at week 24 of treatment. A total of 3174 proteins were identified in our study. Among these proteins, 54 and 154 dysregulated proteins were detected at week 12 and 24 of treatment, respectively, compared with the pretreatment period. |
| HostingRepository | iProX |
| AnnounceDate | 2025-01-15 |
| AnnouncementXML | Submission_2025-07-30_19:42:05.914.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Dahai Wei |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | (13)C labeled residue |
| Instrument | 4800 Plus MALDI TOF/TOF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-01-14 20:10:29 | ID requested | |
| ⏵ 1 | 2025-07-30 19:42:06 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Chronic Hepatitis B |
| PEG-IFN-α |
| NAs |
| Proteomics |
Contact List
| Dahai Wei | |
|---|---|
| contact affiliation | Jiaxing University |
| contact email | weidahai3166@163.com |
| lab head | |
| Dahai Wei | |
| contact affiliation | Jiaxing University |
| contact email | weidahai3166@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
to receive all new ProteomeXchange dataset release announcements!
