PXD059763 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Polystyrene micro- and nanoplastics aggravates colitis in a mouse model – effects on biodistribution, macrophage polarization, and gut microbiome |
| Description | The increasing prevalence of inflammatory bowel disease (IBD) and rising pollution from micro- and nanoplastic (MNP) particles has prompted investigations on their potential interconnection. To elucidate the complex relationship between IBD and exposure to MNPs, we induced colitis in mice using dextran sodium sulfate (DSS) and orally administered a solution of polystyrene (PS) MNPs (diameter 10, 1, and 0.29 µm). These particles enabled a detailed examination of MNP biodistribution, macrophage response, and gut microbiome alterations under inflammatory conditions. Specifically, the nanosized PS particles predominantly accumulated in the bloodstream and excretory organs, with enhanced accumulation in the colitis model. Proteomic analysis of the colon revealed alterations in molecular pathways related to protein transport, metabolism, and immune responses. Specifically, macrophages shifted towards a pro-inflammatory phenotype, highlighting the intricate effects of MNPs on inflammation and immune cell behavior. Moreover, MNPs significantly disrupted the gut microbiome, reducing microbial diversity and shifting bacterial populations towards pro-inflammatory and potentially pathogenic species. These changes suggest that MNP exposure could exacerbate colitis through complex interactions involving MNPs, immune responses, and microbial dynamics. The fast-growing exposure to MNPs underscores the urgent need for comprehensive strategies to address MNP pollution, its implications for disease, and potential impacts on public health |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-22 |
| AnnouncementXML | Submission_2026-05-22_01:24:56.631.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ulrike Resch |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Eclipse; Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-01-14 01:50:46 | ID requested | |
| ⏵ 1 | 2026-05-22 01:24:57 | announced | |
Publication List
Keyword List
Contact List
| Ulrike Resch |
|---|
| contact affiliation | Medical University of Vienna, Department of Vascular Biology and Thrombosis Research, Vienna, Austria |
| contact email | ulrike.resch@meduniwien.ac.at |
| lab head | |
| Ulrike Resch |
|---|
| contact affiliation | Medical University of Vienna, Deptartment of Vascular Biology and Thrombosis Research |
| contact email | ulrike.resch@meduniwien.ac.at |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD059763
- Label: PRIDE project
- Name: Polystyrene micro- and nanoplastics aggravates colitis in a mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
