PXD059736-1

PXD059736 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Activity-based sensing reveals elevated labile copper promotes liver aging via hepatic ALDH1A1 depletion
Description	Oxidative stress plays a key role in aging and related diseases, including neurodegeneration, cancer, and organ failure. Copper (Cu), a redox-active metal ion, generates reactive oxygen species (ROS), and its dysregulation contributes to aging. Here, we develop activity-based imaging probes for the sensitive detection of Cu(I) and show that labile hepatic Cu activity increases with age, paralleling a decline in ALDH1A1 activity, a protective hepatic enzyme. We also observe an age-related decrease in hepatic glutathione (GSH) activity through noninvasive photoacoustic imaging. Using these probes, we perform longitudinal studies in aged mice treated with ATN-224, a Cu chelator, and demonstrate that this treatment improves Cu homeostasis and preserves ALDH1A1 activity. Our findings uncover a direct link between Cu dysregulation and aging, providing insights into its role and offering a therapeutic strategy to mitigate its effects.
HostingRepository	jPOST
AnnounceDate	2025-01-16
AnnouncementXML	Submission_2025-01-16_10:43:33.182.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD059736
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Justine Arrington
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; L-methionine sulfoxide; deamidated L-asparagine; deamidated L-glutamine
Instrument	Orbitrap Fusion ETD; Q Exactive HF-X

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-13 10:51:04	ID requested
⏵ 1	2025-01-16 10:43:33	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: liver, aging, copper, oxidative stress

submitter keyword: liver, aging, copper, oxidative stress

Contact List

Jefferson Chan
lab head
Justine Arrington
contact affiliation	University of Illinois at Urbana-Champaign
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003528/