PXD059735-1

PXD059735 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis of C2C12 myoblasts treated with Tunicamycin
Description	Label free proteomic analysis of C2C12 myoblasts treated with either Tunicamycin (0.2ug/ml) alone or with PERK AMG44 (2uM) for 8h and followed by 16h recovery.
HostingRepository	PRIDE
AnnounceDate	2026-04-27
AnnouncementXML	Submission_2026-04-26_16:43:46.974.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Brian McDonagh
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	N-ethylmaleimide derivatized cysteine
Instrument	LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-13 09:28:29	ID requested
⏵ 1	2026-04-26 16:43:47	announced

Publication List

10.1038/s41418-025-01603-7;
Casas-Martinez JC, Xia Q, Li P, Borja-Gonzalez M, Miranda-Vizuete A, McDermott E, Dockery P, Quinlan LR, Goljanek-Whysall K, Samali A, McDonagh B, Adaptive ER stress promotes mitochondrial remodelling and longevity through PERK-dependent MERCS assembly. Cell Death Differ, 33(4):732-747(2026) [pubmed]

10.1038/s41418-025-01603-7;

Casas-Martinez JC, Xia Q, Li P, Borja-Gonzalez M, Miranda-Vizuete A, McDermott E, Dockery P, Quinlan LR, Goljanek-Whysall K, Samali A, McDonagh B, Adaptive ER stress promotes mitochondrial remodelling and longevity through PERK-dependent MERCS assembly. Cell Death Differ, 33(4):732-747(2026) [pubmed]

Keyword List

submitter keyword: Tunicamycin, ER stress,skeletal muscle, PERK AMG44

submitter keyword: Tunicamycin, ER stress,skeletal muscle, PERK AMG44

Contact List

Brian McDonagh
contact affiliation	Physiology, University of Galway, Ireland
contact email	brian.mcdonagh@universityofgalway.ie
lab head
Brian McDonagh
contact affiliation	University of Galway
contact email	brian.mcdonagh@universityofgalway.ie
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD059735
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD059735

PRIDE project URI

Repository Record List

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