⮝ Full datasets listing
PXD059681-1
PXD059681 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | TOC Phospho-Regulation by the RAF-like Kinase CTR1 is Essential for Chloroplast Biogenesis |
| Description | Chloroplast biogenesis, essential for photosynthesis, depends on the import of nuclear-encoded proteins through TOC (Translocon at the Outer Envelope of Chloroplasts) complexes. Despite its significance, the mechanisms regulating this process remain largely elusive. We identify CTR1 (Constitutive Triple Response 1), a RAF-like kinase known for its role in ethylene signaling, as a key regulator of Toc33, a core TOC component. CTR1 phosphorylates and stabilizes Toc33 by preventing its ubiquitination and degradation independently of the ethylene signaling pathway. Disruption of Toc33 phosphorylation impairs its stability and photosynthetic protein import, which consequently affects chloroplast structural integrity and biogenesis. Our findings underscore the essential role of CTR1-mediated TOC phosphorylation in chloroplast biogenesis, revealing an unexpected link between an ethylene signaling component and organelle development. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-01-13 |
| AnnouncementXML | Submission_2026-01-12_07:00:04.585.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yuanchi Chien |
| SpeciesList | scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: 3702; |
| ModificationList | S-carboxamidomethyl-L-cysteine; O-phospho-L-serine; O-phospho-L-threonine; O4'-phospho-L-tyrosine; L-methionine sulfoxide; alpha-amino acetylated residue |
| Instrument | LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-01-12 08:51:18 | ID requested | |
| ⏵ 1 | 2026-01-12 07:00:05 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Arabidopsis, chloroplast, phosphorylation |
Contact List
| Gyeong Mee Yoon | |
|---|---|
| lab head | |
| Yuanchi Chien | |
| contact affiliation | Purdue University |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003548/ |
