PXD059607-1

PXD059607 is an original dataset announced via ProteomeXchange.

Title	Atlas of lysine propionylation in the human right atrium reveals ALDH6A1-NADH pathway involved in the new-onset atrial fibrillation in aging after coronary artery bypass grafting
Description	Lysine propionylation modification (Kpr) plays an important role in the pathogenesis of several cardiovascular diseases, but the role of Kpr in postoperative atrial fibrillation (POAF) is unclear. Here, we established an atlas of proteomics and propionylation proteomics in the atrial appendage tissues from 28 aging CABG patients, exploring the role of Kpr proteins in the occurrence of POAF. The Kpr of ALDH6A1 was most significantly increased on Lys113 (2.25 folds). The activity of ALDH6A1 increased due to higher binding energy of propionylated ALDH6A1 and NAD+, causing an increase in NADH levels in cells and triggering abnormal energy metabolism. Furthermore, the increase in NADH levels triggered the accumulation of reactive oxygen species, which may cause oxidative stress and cardiac electrical remodeling, resulting in the development of AF. This study reveals the important role of ALDH6A1-NADH pathway in POAF, and provides new insights for exploring the pathogenesis of POAF in CABG.
HostingRepository	PRIDE
AnnounceDate	2025-08-11
AnnouncementXML	Submission_2025-08-11_14:34:39.780.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hai-Tao Hou
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidoethyl-L-cysteine
Instrument	timsTOF HT

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-09 12:37:13	ID requested
⏵ 1	2025-08-11 14:34:40	announced

Zhang Y, Chen HX, Hou HT, Liu YQ, Chen Z, Yang Q, He GW, Atlas of lysine propionylation of human right atrium and ALDH6A1-NADH pathway in new-onset atrial fibrillation after coronary surgery. Commun Biol, 8(1):858(2025) [pubmed]

10.1038/s42003-025-08264-9;

submitter keyword: propionylation,ALDH6A1,atrial fibrillation,coronary artery bypass grafting

Hou HT
contact affiliation	Department of Cardiovascular Surgery & The Institute of Cardiovascular Diseases, TEDA International Cardiovascular Hospital, Tianjin University & Chinese Academy of Medical Sciences
contact email	hhtpk007@163.com
lab head
Hai-Tao Hou
contact affiliation	Teda International Cardiovascular Hospital
contact email	hhtpk007@163.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD059607
     1. Label: PRIDE project
     2. Name: Atlas of lysine propionylation in the human right atrium reveals ALDH6A1-NADH pathway involved in the new-onset atrial fibrillation in aging after coronary artery bypass grafting