PXD059599-1

PXD059599 is an original dataset announced via ProteomeXchange.

Title	TAK285 induced degradation – selectivity profiling in NALM-6 cells
Description	The hit compound TAK285 was subjected to full proteome profiling by TMTpro 6-plex to assess its degradation selectivity in NALM-6 cells. TAK285 induced the degradation of the kinase BLK. The compound was further mechanistically dissected as reported with orthogonal assays such as FACS-based CRISPR/Cas9 screens and BioID.
HostingRepository	PRIDE
AnnounceDate	2025-09-04
AnnouncementXML	Submission_2025-09-04_04:27:03.523.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD059599
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Fabian Frommelt
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-09 08:38:34	ID requested
⏵ 1	2025-09-04 04:27:03	announced

10.6019/PXD059599;

submitter keyword: kinase inhibitors,TMT

Georg E. Winter
contact affiliation	Winter Lab, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
contact email	gwinter@cemm.oeaw.ac.at
lab head
Fabian Frommelt
contact affiliation	CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
contact email	fabian.frommelt@hotmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD059599

PRIDE project URI

• PRIDE
  1. PXD059599
     1. Label: PRIDE project
     2. Name: TAK285 induced degradation – selectivity profiling in NALM-6 cells