PXD059540 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Acetylomic profiling of NaHS-treated EA.hy926 cells |
| Description | Hydrogen sulfide (H₂S) is an endogenous gasotransmitter implicated in the regulation of protein function. This study investigates whether H₂S-derived sulfur species can engage the catalytic Zn²⁺ center of histone deacetylase 6 (HDAC6) and influence HDAC6-dependent deacetylation. Molecular dynamics simulations support accessibility of HS⁻ to the HDAC6 CD2 active-site tunnel, whereas biochemical, biophysical and quantum-chemical analyses support a zinc-dependent interaction and the chemical feasibility of Zn–sulfur coordination. To investigate changes in protein acetylation associated with exogenous H₂S exposure, acetylomic profiling was performed in EA.hy926 cells treated with 60 μM NaHS or vehicle. This dataset contains the acetylomics data comparing NaHS-treated cells with vehicle-treated controls. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-24 |
| AnnouncementXML | Submission_2026-08-23_21:53:26.808.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Chen Sun |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | acetylated residue |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-01-08 00:46:37 | ID requested | |
| ⏵ 1 | 2026-08-23 21:53:27 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Hydrogen sulfide |
| Endothelial cells |
| HPLC-MS. |
Contact List
| Yi-Chun Zhu |
|---|
| contact affiliation | Shanghai Key Laboratory of Bioactive Small Molecules, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University Shanghai Medical College, Shanghai 200032, China. |
| contact email | yczhu@shmu.edu.cn |
| lab head | |
| Chen Sun |
|---|
| contact affiliation | Fudan University |
| contact email | 16111010002@fudan.edu.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD059540 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD059540
- Label: PRIDE project
- Name: Acetylomic profiling of NaHS-treated EA.hy926 cells
