PXD059511-1

PXD059511 is an original dataset announced via ProteomeXchange.

Title	Consequences of PNU 282987 treatment in GCs exposed to 1% O2 for 24 h
Description	Previous studies suggested a role of acetylcholine (ACh) in the regulation of the ovary. A target receptor, alpha 7 nicotinic ACh receptor (CHRNA7; encoded by CHRNA7), is expressed in the human ovary, e.g. by stromal cells, oocytes and human granulosa cells (GCs). The objective of this study was to explore its functions in cultured, in vitro fertilization (IVF)-derived GCs. For this, GCs exposed to 1% O2 were treated with the selective CHRNA7-agonist PNU 282987 for 24 h.
HostingRepository	PRIDE
AnnounceDate	2025-09-02
AnnouncementXML	Submission_2025-09-02_08:18:40.091.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thomas Fröhlich
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Bruker Daltonics timsTOF series

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-07 07:20:56	ID requested
⏵ 1	2025-09-02 08:18:40	announced

10.1093/biolre/ioaf196;

Se, ß, enhausen P, Caban KM, Schneider M, Eubler K, Kreitmair N, Schneider J, Dissen GA, Berg D, Berg U, St, ö, ckl JB, Kunz L, Fr, ö, hlich T, Mayerhofer A, Activation of the Alpha 7 Nicotinic Acetylcholine Receptor (CHRNA7) Limits Hypoxia-induced Inflammatory Responses and Regulates Collagens in Cultured Human Granulosa Cells. Biol Reprod, ():(2025) [pubmed]

submitter keyword: human ovary, inflammation,Acetylcholine

Thomas Fröhlich
contact affiliation	Ludwig-Maximilians-Universität München Genzentrum Laboratory for Functional Genome Analysis Feodor-Lynen-Str. 25 D-81377 München
contact email	frohlich@genzentrum.lmu.de
lab head
Thomas Fröhlich
contact affiliation	Laboratory for Functional Genome Analysis Gene Center Munich Ludwig-Maximilians-Universität Munich (LMU) Feodor-Lynen-Str. 25 81377 Munich Germany
contact email	frohlich@genzentrum.lmu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD059511

PRIDE project URI

• PRIDE
  1. PXD059511
     1. Label: PRIDE project
     2. Name: Consequences of PNU 282987 treatment in GCs exposed to 1% O2 for 24 h