PXD059446-1

PXD059446 is an original dataset announced via ProteomeXchange.

Title	Super-Omics and PCAS Reveal Rheumatoid Arthritis as a Tumor-like Disease
Description	Rheumatoid arthritis (RA) is a debilitating systemic autoimmune disorder that significantly impairs quality of life. To elucidate the molecular alterations driving RA progression, we performed comprehensive super-omics analyses on synovial tissues from patients with joint trauma, arthritis, and RA. These analyses included transcriptomics, proteomics, metabolomics, microbiomics, and fourteen PTMs (phosphorylation, acetylation, lactylation, O-GlcNAc glycosylation, arginine monomethylation, lysine monomethylation, lysine dimethylation, lysine trimethylation, succinylation, malonylation, glutarylation, tyrosine nitration, N-glycosylation, and O-glycosylation). Additionally, we developed a protein-centered association study (PCAS) method to integrate these complex datasets. Using this approach, we identified key proteins, such as STK17B, and its interactors, which may be crucial in RA pathogenesis. Tumor-like features, including aberrant angiogenesis and epithelial-mesenchymal transition, were observed in RA, alongside the potential involvement of oncogenes and tumor suppressor genes. Finally, we constructed a molecular interaction map of RA, providing a comprehensive framework for advancing RA pathogenesis, diagnosis, and therapy.
HostingRepository	iProX
AnnounceDate	2025-01-04
AnnouncementXML	Submission_2025-01-05_19:22:50.316.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Feiyang Ji
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-05 19:22:28	ID requested
⏵ 1	2025-01-05 19:22:50	announced

Dataset with its publication pending

submitter keyword: Super Omics, PCAS

Feiyang Ji
contact affiliation	Zhejiang University
contact email	feiyangji@zju.edu.cn
lab head
Feiyang Ji
contact affiliation	Zhejiang University
contact email	feiyangji@zju.edu.cn
dataset submitter

iProX dataset URI