PXD059422-1

PXD059422 is an original dataset announced via ProteomeXchange.

Title	YTHDF2 regulates self non-coding RNA metabolism to control TLR3 activation in Inflammation
Description	To elucidate the roles of YTHDF2 in the UV response in Human Keratinocyte (HaCaT) cells, the YTHDF2 interactome was analyzed through immunoprecipitation using a YTHDF2-specific antibody. Control IgG served as a negative control in this study. The cells were treated with UVB at 20 mJ/cm², and one hour post-treatment, alterations in the binding partners interacting with YTHDF2, along with their post-translational modifications, were analyzed using proteomics.
HostingRepository	PRIDE
AnnounceDate	2025-09-10
AnnouncementXML	Submission_2025-09-10_06:49:46.191.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD059422
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Seungwon Yang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-03 09:26:30	ID requested
⏵ 1	2025-09-10 06:49:46	announced

10.6019/PXD059422;

ProteomeXchange project tag: Cancer (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: U6, cancer,YTHDF2, TLR3, inflammation, m6A, snRNA, RNA methylation, UVB

Yu-Ying He
contact affiliation	Department of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, USA
contact email	yyhe@uchicago.edu
lab head
Seungwon Yang
contact affiliation	Brigham Women's Hospital (Harvard Medical School)
contact email	syang45@bwh.harvard.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD059422

PRIDE project URI

• PRIDE
  1. PXD059422
     1. Label: PRIDE project
     2. Name: YTHDF2 regulates self non-coding RNA metabolism to control TLR3 activation in Inflammation