PXD059395-1

PXD059395 is an original dataset announced via ProteomeXchange.

Title	Liquid crystal monomers induce placental development and progesterone release dysregulation through transplacental transportation
Description	Embryonic and fetal development can be affected during gestation by exposure to xenobiotics that cross the placenta. Liquid crystal monomers (LCMs) are emerging contaminants commonly found in indoor environments; however, whether they can cross the placenta and affect placental development remains unexplored. Here, we developed an evaluation system that integrates human biomonitoring, uterine perfusion in pregnant rats, and placental cells. We found fourteen out of the fifty-six LCMs that were detected in maternal and cord serum samples from ninety-three healthy pregnant women, at median levels of 13.9 and 18.1 ng/mL, respectively. Subsequent exploration of in utero exposure in rats indicated that aromatic amino acid transporter 1 (SLC16A10) mediated transplacental transportation of the LCMs. Placental cells exposed to LCMs exhibited delayed placental development and reduced progesterone release. These findings showed that SLC16A10-mediated transplacental transportation of LCMs inhibits placental development and progesterone release, highlighting the importance of gestational exposure to emerging contaminants.
HostingRepository	PRIDE
AnnounceDate	2025-01-21
AnnouncementXML	Submission_2025-01-20_19:27:02.391.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhipeng Cheng
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Bruker Daltonics instrument model

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-02 17:01:23	ID requested
⏵ 1	2025-01-20 19:27:02	announced

Dataset with its publication pending

submitter keyword: transporter, gestation exposure, transplacental transportation,LCMs

Zhipeng Cheng
contact affiliation	College of Environmental Science and Engineering, Nankai University
contact email	chengzhipeng@nankai.edu.cn
lab head
Zhipeng Cheng
contact affiliation	Nankai University
contact email	chengzhipeng@nankai.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD059395

PRIDE project URI

• PRIDE
  1. PXD059395
     1. Label: PRIDE project
     2. Name: Liquid crystal monomers induce placental development and progesterone release dysregulation through transplacental transportation