PXD059233-1

PXD059233 is an original dataset announced via ProteomeXchange.

Title	lcpB regulates Staphylococcus aureus virulence and its interaction with host
Description	Staphylococcus aureus is a significant Gram-positive human pathogenic bacterium that can give rise to skin and soft tissue infections and may also result in lethal diseases such as sepsis, pneumonia, endocarditis, osteomyelitis, etc. The cell wall of Staphylococcus aureus is a crucial immunogenic substance and participates in physiological processes like antibiotic resistance and virulence. The previous studies in the laboratory have indicated that the deletion of LCPB can upregulate the virulence of Staphylococcus aureus. However, the specific mechanisms by which LCPB regulates the virulence system of Staphylococcus aureus and its interaction with the host remain unclear. To explore the specific signal pathways by which lcpb regulates the interaction between Staphylococcus aureus and the host, we conducted proteomic experiments. This research discovered that both the knockout of LCPB and the application of WTA synthesis inhibitors can prevent the synthesis of the main component of the cell wall, wall teichoic acid (WTA), and upregulate the expression of excreted virulence factors such as HlgA, LukAB, and hla in Staphylococcus aureus. Subsequently, it was found that the central virulence regulation system agr of Staphylococcus aureus can respond to the reduction of WTA content, and the activation of agr is dependent on the expression of the two-component signal system saeRS.
HostingRepository	iProX
AnnounceDate	2024-12-25
AnnouncementXML	Submission_2024-12-24_19:54:18.196.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ping Yan
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-24 19:54:04	ID requested
⏵ 1	2024-12-24 19:54:18	announced

Dataset with its publication pending

submitter keyword: Staphylococcus aureus, lcpB, WTA

Baolin Sun
contact affiliation	University of Science and Technology of China
contact email	sunb@ustc.edu.cn
lab head
Ping Yan
contact affiliation	University of Science and Technology of China
contact email	2059004454@qq.com
dataset submitter

iProX dataset URI