PXD059218-1

PXD059218 is an original dataset announced via ProteomeXchange.

Title	Proteomics Data of "Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema" Study
Description	Background: Chronic hand eczema (CHE) is a debilitating skin condition characterized by pain, itch, and chronic inflammation, with a complex multifactorial origin. Its diverse presentations, including overlapping traits of atopic dermatitis, contact dermatitis, and psoriasis, make diagnosis and treatment particularly challenging. The underlying immune mechanisms of CHE still need to be investigated. Methods: Here we conducted a comprehensive molecular profiling of CHE patients, enrolled without prior selection on etiology and morphology, and performed a phase 2b randomized, multicenter, double-blind, placebo-controlled clinical trial comparing dupilumab to placebo over 16 weeks. Results: We demonstrated that CHE patients may benefit from IL4Rα-blockade, regardless of etiological factors or clinical presentation. Skin transcriptomic and serum profiles of CHE patients closely resemble those seen in both atopic dermatitis and psoriasis, with dysregulated genes affecting keratinocyte differentiation, leucocyte-mediated immunity, cytokine signaling, and mixed type 1, 2, and 3 immunity. The clinical trial included 94 adults with moderate to severe CHE persisting for at least six months and resistant to potent topical corticosteroids. Compared to placebo control, 16-week dupilumab treatment significantly improved clinical severity and quality of life of all CHE patients while largely restoring appropriate transcriptomic and proteomic programs related to skin barrier and immune homeostasis. Conclusion: These findings confirmed the involvement of not only type 2 but also type 1 and type 3 immunity across all CHE patients, and demonstrate that IL-4Rα blockade may offer effective therapeutic perspectives for this highly burdensome condition, independent of an atopic dermatitis background.
HostingRepository	PRIDE
AnnounceDate	2026-02-26
AnnouncementXML	Submission_2026-02-26_02:55:16.730.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD059218
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Rüçhan Ekren
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-24 07:33:53	ID requested
⏵ 1	2026-02-26 02:55:17	announced

Gery P, Ekren R, B, é, rard E, Du-Thanh A, Rimet H, Jendoubi F, Lenief V, Raison-Peyron N, Bouznad A, Konstantinou MP, Rioual J, Basso L, Mouiren J, Boussier M, Milpied B, Bulai Livideanu C, Jaulent L, Hacard F, Lefevre MA, Nosbaum A, Seneschal J, Vocanson M, Paul C, Gaudenzio N, Tauber M, Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema. Allergy, ():(2026) [pubmed]

10.1111/all.70263;

10.6019/PXD059218;

submitter keyword: None

Nicolas Gaudenzio
contact affiliation	Neural regulation of immune response Lab Toulouse Institute for Infectious and Inflammatory Diseases (Infinity) Hôpital Purpan, Place du Dr Baylac TSA 40031, 31059 Toulouse cedex 9 France
contact email	nicolas.gaudenzio@inserm.fr
lab head
Rüçhan Ekren
contact affiliation	Neural regulation of immune response Lab Toulouse Institute for Infectious and Inflammatory Diseases (Infinity) Hôpital Purpan, Place du Dr Baylac TSA 40031, 31059 Toulouse cedex 9 France
contact email	ruchan.ekren@inserm.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD059218

PRIDE project URI

• PRIDE
  1. PXD059218
     1. Label: PRIDE project
     2. Name: Proteomics Data of "Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema" Study