PXD059204-1

PXD059204 is an original dataset announced via ProteomeXchange.

Title	Integrated Analysis of Proteomics and Metabolomics in Infantile Epileptic Spasms Syndrome
Description	Objective: This study aims to investigate the pathogenic mechanisms of IESS, utilizing metabolomics and proteomics analyses to uncover potential biomarkers for the disease, thereby providing new insights for diagnostic and therapeutic strategies. Methods: Cerebrospinal fluid samples from 6 IESS patients and 6 control subjects with benign intracranial hypertension were collected and analyzed using metabolomics and proteomics techniques. Significant differential metabolites and proteins were identified and correlated to determine key proteins associated with specific metabolites. The study then expanded the sample size to 10 per group and validated the identified proteins through ELISA analysis.
HostingRepository	iProX
AnnounceDate	2024-12-23
AnnouncementXML	Submission_2025-10-30_01:34:53.116.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jun Chen
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-23 19:53:04	ID requested
⏵ 1	2025-10-30 01:34:54	announced

Chen J, Wang X, Rao X, Luo H, Shen Y, Gan J, Integrated analysis of proteomics and metabolomics in infantile epileptic spasms syndrome. Sci Rep, 15(1):4457(2025) [pubmed]

submitter keyword: Infantile Epileptic Spasms Syndrome, Metabolomics, Proteomics, Linoleic Acid Metabolism

Jing Gan
contact affiliation	Sichuan University West China Second University Hospital
contact email	gordonrachel@scu.edu.cn
lab head
Jun Chen
contact affiliation	Sichuan University West China Second University Hospital
contact email	junchenbjc@163.com
dataset submitter

iProX dataset URI