PXD059137-1

PXD059137 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic profiling of PRLX-93936 and structurally similar compounds in pancreatic cancer cells.
Description	To determine the downstream molecular mechanism of PRLX-93936, we performed systematic proteomic profiling of cells treated with PRLX-93936, erastin, or JWZ-8-103. Results include global proteome profiling, ubiquitylation proteomics, and proximity labeling proteomics enabling comparison of drug-induced changes across modalities. This PRIDE entry contains raw proteomics data and FragPipe analyzed search files.
HostingRepository	PRIDE
AnnounceDate	2025-08-18
AnnouncementXML	Submission_2025-08-17_17:02:53.092.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Brendan Dwyer
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF HT

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-22 18:20:05	ID requested
⏵ 1	2025-08-17 17:02:53	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: proximity labeling proteomics,pancreatic cancer, global proteome profiling, PANC-1 cells, LFQ, diaPASEF, ubiquitylation proteomics

submitter keyword: proximity labeling proteomics,pancreatic cancer, global proteome profiling, PANC-1 cells, LFQ, diaPASEF, ubiquitylation proteomics

Contact List

Steven Corsello
contact affiliation	Departments of Medicine (Oncology) and of Chemical and Systems Biology, Stanford School of Medicine, Stanford, CA, USA Stanford Cancer Institute, Stanford, CA, USA
contact email	corsello@stanford.edu
lab head
Brendan Dwyer
contact affiliation	Stanford University
contact email	dwyermrbrendan@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD059137
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD059137

PRIDE project URI

Repository Record List

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