PXD059134-2

PXD059134 is an original dataset announced via ProteomeXchange.

Title	Proteomic data of Fto-depleted skin and the control skin
Description	Lentivirus expressing shRNA targeting Fto was intradermally injected into the back skin of wild-type C57BL/6j mice to locally knock down the expression of FTO in the skin. the proteome of control skin [shNC], Fto-depleted skin [shFto] were analysed by LC‒MS/MS.
HostingRepository	iProX
AnnounceDate	2024-12-20
AnnouncementXML	Submission_2025-08-14_23:42:06.666.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fan Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-22 18:00:09	ID requested
1	2024-12-22 18:00:21	announced
⏵ 2	2025-08-14 23:42:07	announced	2025-08-15: Add info.

Wang F, Zhou L, Zhong Y, Cai Y, Meng X, Chen M, Mao R, Xiao X, Yi C, Guo Y, Xie H, Zhang Y, Li J, Depletion of Fat Mass and Obesity-Associated Protein (FTO) Drives Heterochromatin Loss via Lysine Acetyltransferase 8 (KAT8)-Mediated Remodeling and Spacing Factor 1 (RSF1) Acetylation in Skin Aging. MedComm (2020), 6(7):e70205(2025) [pubmed]

submitter keyword: Proteomic analysis, Fto, skin

Ji Li
contact affiliation	Department of Dermatology, Xiangya Hospital, Central South University
contact email	liji_xy@csu.edu.cn
lab head
Fan Wang
contact affiliation	Department of Dermatology, Xiangya Hospital, Central South University
contact email	228102102@csu.edu.cn
dataset submitter

iProX dataset URI