PXD059109 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | An integrative proteotranscriptomics approach reveals new ADAM9 substrates and downstream pathways |
| Description | An integrative proteotranscriptomics approach to uncover the transcriptional and post-transcriptional targets of the disintegrin metalloproteinase ADAM9, a sheddase that has been implicated in solid tumors, autoimmunity, inflammatory diseases and COVID-19. This systematic approach revealed signaling pathways downstream of ADAM9, including the oncogenic mTOR and tumor suppressor FOXO pathways. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-13 |
| AnnouncementXML | Submission_2026-04-12_17:04:53.785.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD059109 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Congyu Lu |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-12-20 15:40:46 | ID requested | |
| ⏵ 1 | 2026-04-12 17:04:54 | announced | |
Publication List
| 10.1016/j.mcpro.2026.101538; |
| Lu C, Xu X, Sindhu N, Rainey J, Zhang Y, Polson SW, Qiu J, Wei S, An Integrative Proteotranscriptomics Approach Reveals New ADAM9 Substrates and Downstream Pathways. Mol Cell Proteomics, 25(4):101538(2026) [pubmed] |
| 10.6019/PXD059109; |
Keyword List
| submitter keyword: multiomics, metalloproteinase, proteotranscriptomics, integration,ADAM9, target identification |
Contact List
| Shuo Wei |
|---|
| contact affiliation | Department of Biological Sciences, University of Delaware, USA |
| contact email | swei@udel.edu |
| lab head | |
| Congyu Lu |
|---|
| contact affiliation | University of Delaware |
| contact email | congyulu@udel.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD059109 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD059109
- Label: PRIDE project
- Name: An integrative proteotranscriptomics approach reveals new ADAM9 substrates and downstream pathways
