PXD059055-1

PXD059055 is an original dataset announced via ProteomeXchange.

Title	The combined action of suicide gene exosomes from pancreatic cancer-associated fibroblasts and from mesenchymal stem cells as a pancreatic ductal adenocarcinoma treatment approach
Description	Exosomes from pancreatic cancer-associated fibroblasts and mesenchymal stem cells that have been transduced with the yeast cytosine deaminase::uracil phosphoribosyl transferase release suicide gene exosomes acting as "Trojan horse" drugs, effectively killing pancreatic cancer cells by converting the non-toxic prodrug 5-fluorocytosine intracellularly into the cytotoxic 5-fluorouracil. We have shown in experiments in vitro, involving a simulated desmoplastic pancreatic tumor, that the combined action of these targeted exosomes could be an approach for pancreatic ductal adenocarcinoma treatment.
HostingRepository	PRIDE
AnnounceDate	2025-08-09
AnnouncementXML	Submission_2025-08-08_16:33:11.827.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Václav Pustka
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-19 11:26:40	ID requested
⏵ 1	2025-08-08 16:33:12	announced

10.1016/J.BIOPHA.2025.118428;

submitter keyword: pancreatic cancer-associated fibroblasts, mesenchymal stem cells,gene-directed enzyme prodrug therapy, pancreatic cancer intracellular treatment, suicide gene exosomes

Zbynek Zdrahal
contact affiliation	Proteomics Core Facility and Research Group Proteomics, CEITEC-MU, Masaryk University, Brno, Czech Republic
contact email	zdrahal@sci.muni.cz
lab head
Václav Pustka
contact affiliation	Proteomics Core Facility and Research Group Proteomics CEITEC-MU Masaryk University Brno, Czech Republic
contact email	vaclav.pustka@ceitec.muni.cz
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD059055

PRIDE project URI

• PRIDE
  1. PXD059055
     1. Label: PRIDE project
     2. Name: The combined action of suicide gene exosomes from pancreatic cancer-associated fibroblasts and from mesenchymal stem cells as a pancreatic ductal adenocarcinoma treatment approach