PXD059031-1

PXD059031 is an original dataset announced via ProteomeXchange.

Title	Multi-Omic study on metastatic characteristics of oral cancer at early stage
Description	Oral cancer accounts for nearly 3% of all cancer cases and is becoming an increasingly frequent clinical problem in Asia. A strong tendency for loco-regional invasion and metastasis are the remarkable biological characteristics of OSCC，which is also a leading cause for the failure of treatment. Early stage of OSCC is defined as cT1-2N0M0. Operation is regarded as the first choice for treatment of OSCC. Excision of the primary tumor is essential with no doubt. However, surgical options for addressing the neck are contentious. The incidence of occult neck metastasis ranges from 8.5% to 45%, at average of 25.4%, while occult metastases can hardly be detected clinically or radiographically. If the neck dissection is not included in the therapy plan, the cN0 patients may experience increased mortality. However, the majority of early-stage OSCC patients, actually with no metastasis, may suffer from unnecessary iatrogenic injury and postoperative complications. Moreover, up to now, it is unclear for these cT1-2N0 OSCC, which are prone to metastasis. By integrating mass spectrometry (MS)-based proteomics with genomics and transcriptomics, we aim to investigate the different molecular features of primary lesions between pN0 and pN+.
HostingRepository	iProX
AnnounceDate	2024-12-19
AnnouncementXML	Submission_2024-12-18_22:38:58.851.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Qiuhan Zheng
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	iTRAQ8plex reporter+balance reagent acylated residue; deamidated residue; oxidation; S-carboxamidomethyl-L-cysteine
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-18 22:38:38	ID requested
⏵ 1	2024-12-18 22:38:59	announced

Dataset with its publication pending

submitter keyword: Multi-Omic, OSCC, OSCC in early, neck metastasis

Yujie Liang
contact affiliation	Hospital of stomatology, Sun Yat-sen University
contact email	liangyj35@mail.sysu.edu.cn
lab head
Qiuhan Zheng
contact affiliation	Hospital of stomatology, Sun Yat-sen University
contact email	zhengqh3@mail2.sysu.edu.cn
dataset submitter

iProX dataset URI