PXD058999 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Membrane proteomic profiling to identify candidate therapy targets for glioblastoma infiltration |
| Description | Isocitrate dehydrogenase wild type glioblastoma (GBM) is an aggressive brain tumour characterized by rapid growth and infiltration into adjacent functional brain tissue. Presently, treatment is restricted to surgical resection followed by temozolomide chemotherapy and concomitant radiotherapy; however, new therapies are desperately needed to improve GBM patient outcome. Intra-tumoural heterogeneity is a common driver of failure for novel GBM treatments, and many preclinical studies rely on cell lines established from the tumour core. As a result, they fail to characterise the infiltrative cells which remain post-surgery and ultimately drive tumour recurrence. This study characterises the membrane proteome of 3 patient-derived GBM cell lines isolated from the tumour infiltrative margin (GIN8, GIN28, and GIN31), which are a proxy for residual disease post-surgery. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-07 |
| AnnouncementXML | Submission_2026-09-06_16:19:38.144.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | David Boocock |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | ZenoTOF 7600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-12-18 08:18:03 | ID requested | |
| ⏵ 1 | 2026-09-06 16:19:38 | announced | |
Publication List
| 10.1093/noajnl/vdag181; |
| Porter H, Mulhall K, Shah M, Vinohar JJ, Karadimas KP, Mistry S, Deacon S, Haque F, Bakker E, Boocock DJ, Coveney C, Layfield R, Rahman R, McCrorie P, Membrane proteomic profiling to identify candidate therapy targets for glioblastoma infiltration. Neurooncol Adv, 8(1):vdag181(2026) [pubmed] |
Keyword List
| submitter keyword: membrane glioblastoma astrocyte infiltration |
Contact List
| David John Boocock |
|---|
| contact affiliation | John van Geest Cancer Research Centre, Nottingham Trent University |
| contact email | david.boocock@ntu.ac.uk |
| lab head | |
| David Boocock |
|---|
| contact affiliation | Nottingham Trent University |
| contact email | david.boocock@ntu.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD058999 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD058999
- Label: PRIDE project
- Name: Membrane proteomic profiling to identify candidate therapy targets for glioblastoma infiltration
