PXD058779-1

PXD058779 is an original dataset announced via ProteomeXchange.

Title	Increased APOE abundance in the brain in Down syndrome - Alzheimer’s disease compared with early onset-Alzheimer's disease is associated with elevated APP and its processing products
Description	Trisomy of chromosome 21, the cause of Down syndrome (DS), is the most commonly occurring genetic cause of Alzheimer’s disease (AD). Here we compare the proteome of the frontal cortex of people who have Down syndrome-Alzheimer’s disease (DSAD) with demographically matched cases of early-onset AD and healthy ageing controls from the general population. We find the abundance of several chromosome 21 encoded proteins are increased in DSAD compared to both comparative groups. Moreover, wider dysregulation of the proteome occurs beyond proteins encoded by chromosome 21, including an increase in the abundance of the key AD protein APOE, in people with DSAD compared to matched cases of early-onset AD.
HostingRepository	PRIDE
AnnounceDate	2025-02-26
AnnouncementXML	Submission_2025-02-26_13:05:22.222.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD058779
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Cliona Farrell
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-11 08:48:37	ID requested
⏵ 1	2025-02-26 13:05:22	announced

10.6019/PXD058779;

10.1101/2025.02.24.639862;

submitter keyword: brain, Alzheimer's disease, Apolipoprotein E,Down syndrome

Frances K Wiseman
contact affiliation	UK Dementia Research Institute, UCL Queen Square Institute of Neurology, University College London, United Kingdom
contact email	f.wiseman@ucl.ac.uk
lab head
Cliona Farrell
contact affiliation	University College London, UK Dementia Research Institute
contact email	cliona.farrell.20@ucl.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/02/PXD058779

PRIDE project URI

• PRIDE
  1. PXD058779
     1. Label: PRIDE project
     2. Name: Increased APOE abundance in the brain in Down syndrome - Alzheimer’s disease compared with early onset-Alzheimer's disease is associated with elevated APP and its processing products