PXD058740 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | PTBP1 and PTBP2 associate with distinct proteins and have distinct post-translational modifications in nuclear neuronal extract. |
| Description | PTBP1 and PTBP2 are highly conserved paralogs, yet exhibit distinct splicing patterns. Here we use mass spectrometry to show that PTBP1 and PTBP2 interact with distinct proteins and undergo distinct post translational modifications under splicing conditions in neuronal nuclear extract. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-09 |
| AnnouncementXML | Submission_2026-02-08_16:25:17.423.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Michael Sullivan |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monomethylated residue; phosphorylated residue; acetylated residue |
| Instrument | Orbitrap Fusion Lumos; timsTOF Pro 2 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-12-10 12:45:10 | ID requested | |
| ⏵ 1 | 2026-02-08 16:25:18 | announced | |
Publication List
| 10.1371/journal.pone.0325143; |
| Sullivan ME, Edberg JA, Nunez CI, Axelrod HL, Keppetipola NM, Polypyrimidine tract binding proteins PTBP1 and PTBP2 associate with distinct proteins and have distinct post-translational modifications in neuronal nuclear extract. PLoS One, 20(6):e0325143(2025) [pubmed] |
Keyword List
| submitter keyword: post-translational modificantions,PTBP1, Mass Spectrometry, Splicing, PTBP2, Protein-protein interactions |
Contact List
| Niroshika Keppetipola |
|---|
| contact affiliation | Department of Chemistry and Biochemistry. California State University, Fullerton. |
| contact email | nkeppetipola@fullerton.edu |
| lab head | |
| Michael Sullivan |
|---|
| contact affiliation | University of North Carolina at Chapel Hill |
| contact email | michsull@ad.unc.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD058740 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD058740
- Label: PRIDE project
- Name: PTBP1 and PTBP2 associate with distinct proteins and have distinct post-translational modifications in nuclear neuronal extract.
