PXD058684-1
PXD058684 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mouse multi-organ age-associated protein changes across life stages |
| Description | Ageing is a key risk factor for disease and mortality in humans and other animals, with most insights derived from genomic, epigenomic, and transcriptomic studies. However, large-scale datasets on age-related changes at the protein level remain scarce. To fill this gap, we performed a comprehensive quantitative proteomic analysis across eight major organs—brain, heart, lungs, liver, kidneys, spleen, skeletal muscle, and testis—in male C57BL/6J mice, sampled at key life stages: young adult (3–5 months), adult (8 months), mid-life (14 months), and late life (20–26 months). Our results revealed diverse rates of protein expression changes, ranging from rapid (kidneys, spleen) to moderate (liver, lungs) to minimal (skeletal muscle, testis) and subtle (heart, brain). Aging onset appeared earlier in the spleen and kidneys compared to the liver and lungs. By isolating the non-blood proteome, we identified enriched organ-specific processes like oxidative phosphorylation (kidneys) and lipid metabolism (liver), along with shared processes across organs. These findings provide valuable insights into organ-specific and shared protein dynamics underlying age-related diseases. |
| HostingRepository | jPOST |
| AnnounceDate | 2025-06-17 |
| AnnouncementXML | Submission_2025-06-16_08:29:21.302.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Enzo Scifo |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
| ModificationList | S-carboxamidomethyl-L-cysteine; N6-acetyl-L-lysine; alpha-amino acetylated residue; L-methionine sulfoxide |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-12-08 23:25:09 | ID requested | |
| ⏵ 1 | 2025-06-16 08:29:21 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: ageing, mass spectrometry, mouse organs, protein trajectories, SureQuant |
Contact List
| Dr. Dan Ehninger | |
|---|---|
| lab head | |
| Enzo Scifo | |
| contact affiliation | DZNE |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003472/ |
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