PXD058627 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | - Pharmacological inhibition of deoxyhypusine synthase with GC7 in three PCa cell lines (LNCaP and DU145) |
| Description | Protein synthesis plays a central role in cancer development and progression. eIF5A (eukaryotic initiation factor 5A), a translation factor activated by hypusination, is implicated in tumorigenesis, however, its mode of action is still unclear. Hypusinated eIF5A (eIF5Ahyp) promotes metastasis and tumor growth in prostate cancer (PCa) by supporting mitochondrial metabolism and translation. To characterize the pro-tumorigenic role of eiF5Ahyp in PCa, we employed pharmacological inhibition of deoxyhypusine synthase (DHPS) with GC7 in two PCa cell lines (LNCaP and DU145) coupled with quantitative proteomics. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-30 |
| AnnouncementXML | Submission_2026-01-30_07:01:30.283.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Luc Camoin |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-12-05 12:33:41 | ID requested | |
| ⏵ 1 | 2026-01-30 07:01:30 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Hypusination, Prostate Cancer, Quantitative Proteomics,eIF5A |
Contact List
| Luc Camoin |
|---|
| contact affiliation | Marseille Proteomique, Inserm U1068, CNRS UMR7258, Aix Marseille Université U105 |
| contact email | luc.camoin@inserm.fr |
| lab head | |
| Luc Camoin |
|---|
| contact affiliation | Life Sciences |
| contact email | luc.camoin@inserm.fr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD058627 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD058627
- Label: PRIDE project
- Name: - Pharmacological inhibition of deoxyhypusine synthase with GC7 in three PCa cell lines (LNCaP and DU145)
