PXD058616-1

PXD058616 is an original dataset announced via ProteomeXchange.

Title	The histone modification regulator, SIN3, plays a role in the cellular response to changes in glycolytic flux
Description	Epigenetic regulation and metabolism are connected. Epigenetic regulators, like the SIN3 complex, affect the expression of a wide range of genes, including those encoding metabolic enzymes essential for central carbon metabolism. The idea that epigenetic modifiers can sense and respond to metabolic flux by regulating gene expression has long been proposed. In support of this cross-talk, we provide data linking SIN3 regulatory action on a subset of metabolic genes with the cellular response to changes in metabolic flux. Furthermore, we show that loss of SIN3 is linked to decreases in mitochondrial respiration and the cellular response to mitochondrial and glycolytic stress. Data presented here provide evidence that SIN3 is important for the cellular response to metabolic flux change.
HostingRepository	PRIDE
AnnounceDate	2025-10-14
AnnouncementXML	Submission_2025-10-14_14:40:10.604.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD058616
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Paul Stemmer
SpeciesList	scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: NEWT:7227;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-05 08:53:33	ID requested
⏵ 1	2025-10-14 14:40:11	announced

10.6019/PXD058616;

submitter keyword: histone modification, respiration, gene regulation, energy metabolism, Drosophila

Lori Pile
contact affiliation	Wayne State University
contact email	loripile@wayne.edu
lab head
Paul Stemmer
contact affiliation	Wayne State University
contact email	pmstemmer@wayne.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD058616
     1. Label: PRIDE project
     2. Name: The histone modification regulator, SIN3, plays a role in the cellular response to changes in glycolytic flux