PXD058552-1

PXD058552 is an original dataset announced via ProteomeXchange.

Title	Proteoform Imaging by Combining MALDI MSI and High-sensitivity Top-down Proteomics
Description	Spatially resolved characterization of proteoforms has great potential to significantly advance our understanding of physiological and disease mechanisms. However, it faces challenges regarding throughput and coverage. Herein, we developed a robust method for high-throughput proteoform imaging (HTPi) by combining matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) and region-specific top-down proteomic analysis.
HostingRepository	iProX
AnnounceDate	2024-12-03
AnnouncementXML	Submission_2025-08-13_20:34:05.423.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yue Sun
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	acetylated residue; phosphorylated residue
Instrument	Orbitrap Fusion Lumos; ultraflex III TOF/TOF

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-03 22:18:54	ID requested
⏵ 1	2025-08-13 20:34:06	announced

Sun Y, Liu D, Liang Y, Yang X, Liu X, Zhao B, Liang Z, Zhang Y, Zhang L, High-Throughput Proteoform Imaging for Revealing Spatial-Resolved Changes in Brain Tissues Associated with Alzheimer's Disease. Adv Sci (Weinh), 12(17):e2416722(2025) [pubmed]

submitter keyword: proteoforms, top-down proteomics, mass spectrometry imaging

Lihua Zhang
contact affiliation	Dalian Institute of Chemical Physics, Chinese Academy of Sciences
contact email	lihuazhang@dicp.ac.cn
lab head
Yue Sun
contact affiliation	Dalian Institute of Chemical Physics, Chinese Academy of Sciences&University of Chinese Academy of Sciences
contact email	yuesun@dicp.ac.cn
dataset submitter

iProX dataset URI