⮝ Full datasets listing
PXD058513-1
PXD058513 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Lysine-targeting, covalent inhibitors of bromodomain BD1 of BET proteins in live cells and animals |
| Description | We report herein a set of activity-based probes (ABPs; P3-P7) based on various lysine-reactive covalent warheads capable of global profiling of ligandable lysine within BRDs in live cells and animals. Chemoproteomic experiments with P7 by utilizing 2-ethynylbenzaldehyde (EBA) identified 18 endogenous BRDs, thus giving a global landscape of ligandable lysines in BRDs. |
| HostingRepository | iProX |
| AnnounceDate | 2025-04-10 |
| AnnouncementXML | Submission_2025-05-05_21:46:31.147.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Rui Wang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-12-02 23:44:14 | ID requested | |
| ⏵ 1 | 2025-05-05 21:46:31 | announced |
Publication List
Keyword List
| submitter keyword: Brds, Chemoproteomic |
Contact List
| Yusheng Xie | |
|---|---|
| contact affiliation | Shandong University |
| contact email | yushengxie@sdu.edu.cn |
| lab head | |
| Rui Wang | |
| contact affiliation | Shenzhen Bay Laboratory |
| contact email | wangrui@szbl.ac.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
