PXD058460-1

PXD058460 is an original dataset announced via ProteomeXchange.

Title	Moderate-Intensity Interval Exercise Exacerbates Cardiac Lipotoxicity in High-Fat, High-Calories Diet-Fed Mice
Description	Physical exercise is a cornerstone for preventing diet-induced obesity, while it is unclear whether physical exercise could offset high-fat, high-calories diet (HFCD)-induced cardiac dysfunction. Here, mice were fed with HFCD and simultaneously subjected to physical exercise. As expected, physical exercise prevented HFCD-induced whole-body fat deposition. However, physical exercise exacerbated HFCD-induced cardiac damage. Further metabolomic analysis results showed that physical exercise induced circulating lipid redistribution, leading to excessive cardiac lipid uptake and lipotoxicity. Our study provides valuable insights into the cardiac effects of exercise in mice fed with HFCD, suggesting that counteracting the negative effect of HFCD by simultaneous physical exercise might be detrimental. Moreover, inappropriate physical exercise may damage certain organs even though it leads to weight loss and overall metabolic benefits. Of note, the current findings are based on animal experiments, the generalizability of these findings beyond this specific diet and mouse strain remains to be further explored.
HostingRepository	iProX
AnnounceDate	2024-11-30
AnnouncementXML	Submission_2024-12-01_23:29:08.560.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lang Hu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-01 23:28:54	ID requested
⏵ 1	2024-12-01 23:29:08	announced

Dataset with its publication pending

submitter keyword: exercise, lipotoxicity, high fat feed

Lang Hu
contact affiliation	Department of Cardiology, Tangdu Hospital, Airforce Medical University
contact email	medhulang@163.com
lab head
Lang Hu
contact affiliation	Department of Cardiology, Tangdu Hospital, Airforce Medical University
contact email	medhulang@163.com
dataset submitter

iProX dataset URI