⮝ Full datasets listing
PXD058455-1
PXD058455 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Intestinal microenvironment intervention by live and heat-inactivated Bifidobacterium animalis J12 before pregnancy ameliorates neurodevelopmental abnormalities in prenatally stressed rat offspring by activating focal adhesion pathways in hippocampus |
| Description | Prenatal stress has the potential to induce emotional and cognitive impairments in the progeny, impacting their neurological growth significantly. It is still unknown whether intestinal microenvironment intervention by probiotics before pregnancy can alleviate PS and improve the health of the offspring.This findings provided that B. animalis J12 live and heat-inactivated cells significantly reduced the concentration of corticosterone in serum of PS rats, ameliorated the neurological damage and increased the abundance of neurodevelopmentally beneficial species in the intestine of offspring, such as Lactobacillus, Romboutsia, unclassified__f__Oscillospiraceae, unclassified__f__Lachnospiraceae, and others. B. animalis J12 live and heat-inactivated cells increased the intestinal levels of Sterigmatocystin and Phosphocreatine. By modulating the structure of intestinal flora, B. animalis J12 live cells activated the focal adhesion pathway and inhibited complement activation, heat-inactivated cells activated the focal adhesion pathway and increased the expression of glutamine transporter proteins to alleviate neurological damage and neuroinflammation, and to improve learning and memory disorders as well as affective disorders. |
| HostingRepository | iProX |
| AnnounceDate | 2024-11-30 |
| AnnouncementXML | Submission_2025-11-30_23:09:51.584.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yumeng Ma |
| SpeciesList | scientific name: Rattus norvegicus; NCBI TaxID: 10116; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-12-01 23:20:22 | ID requested | |
| ⏵ 1 | 2025-11-30 23:09:52 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: probiotics, prenatal stress, Progeny neurodevelopment, Learning and memory impairment |
Contact List
| Junhua Jin | |
|---|---|
| contact affiliation | Beijing University of Agriculture |
| contact email | jinjunhua002008@163.com |
| lab head | |
| Yumeng Ma | |
| contact affiliation | Beijing University of Agriculture |
| contact email | m15210115481@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
