PXD058441 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Human brain prefrontal cortex proteomics identifies compromised energy metabolism and neuronal function in Schizophrenia |
| Description | Understanding the pathophysiological substrates of schizophrenia is a major challenge for current neuropsychiatric research. As part of a set of multi-omics experiments, we performed an extensive case-control proteomics study on 192 post-mortem tissue sections from prefrontal cortex from 96 individuals, including 47 cases with schizophrenia and 49 healthy controls. Using two independently measured cortical datasets, we identified 387 proteins differentially expressed between schizophrenia cases and controls at a 5% FDR threshold. This significantly regulated set of proteins contains genes located in GWAS-identified schizophrenia loci and proteins identified by pQTL analysis. Gene ontology analysis using GOAT provided evidence for regulation of several major protein categories, emphasizing downregulation of mitochondrial oxidative respiration, ribosomes and the proteasome, upregulation of kinases and (small) GTPases. SynGO analysis supports the notion of synaptic dysfunction in schizophrenia, with major regulators of pre- and postsynaptic function compromised. Our findings highlight the complex molecular dysregulation in schizophrenia, with mitochondrial function downregulated versus signaling and trafficking upregulated, and synapse function disrupted; in combination with prior avenues of research, these finding support a role for energy deficits compromising highly ATP dependent neuronal function as a target for therapeutic interventions. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-11 |
| AnnouncementXML | Submission_2026-03-11_01:14:28.186.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Frank Koopmans |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro 2 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-12-01 10:05:32 | ID requested | |
| ⏵ 1 | 2026-03-11 01:14:29 | announced | |
Publication List
| Koopmans F, Dijkstra AA, Li WP, Klaassen RV, Gouwenberg Y, Yao S, Bast L, Verhage M, Karlsson R, Dwork AJ, Stockmeier CA, Hjerling-Leffler J, Sullivan PF, Smit AB, Human brain prefrontal cortex proteomics identifies compromised energy metabolism and neuronal function in Schizophrenia. Nat Commun, 17(1):(2026) [pubmed] |
| 10.1038/s41467-026-68950-y; |
Keyword List
Contact List
| August B. Smit |
|---|
| contact affiliation | Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research (CNCR), Amsterdam Neuroscience, VU University Amsterdam, The Netherlands |
| contact email | guus.smit@vu.nl |
| lab head | |
| Frank Koopmans |
|---|
| contact affiliation | Vrije Universiteit Amsterdam |
| contact email | frank.koopmans@vu.nl |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD058441 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD058441
- Label: PRIDE project
- Name: Human brain prefrontal cortex proteomics identifies compromised energy metabolism and neuronal function in Schizophrenia
