PXD058362-1

PXD058362 is an original dataset announced via ProteomeXchange.

Title	Wild-type KRAS activation drives evasion of interferon-mediated immunity and resistance to immunotherapy in hepatocellular carcinoma
Description	Increasing evidence indicates that activation of oncogenic pathways contributes to an unfavourable tumour immune microenvironment (TIME), ultimately resulting in resistance to immunotherapy. Here, we aim to identify a critical oncogenic pathway involved in an antigen-expressing c-MYC-lucOSOE/Tp53KO HCC mouse model that simulates immune response against tumour-associated antigens in human HCC. To investigate the intrinsic oncogenic pathway enriched in tumours exhibiting immune evasion, tumour tissues were harvested from c-MYC-lucOE/Tp53KO mice and immune-escaped c-MYC-lucOSOE/Tp53KO mice for DIA proteomics.
HostingRepository	PRIDE
AnnounceDate	2025-09-18
AnnouncementXML	Submission_2025-09-18_03:19:18.095.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD058362
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	MANG LENG LEI
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-27 21:21:59	ID requested
⏵ 1	2025-09-18 03:19:18	announced

10.6019/PXD058362;

submitter keyword: Hepatocellular carcinoma

Terence Lee
contact affiliation	ABCT, The Hong Kong Polytechnic University
contact email	terence.kw.lee@polyu.edu.hk
lab head
MANG LENG LEI
contact affiliation	The Hong Kong Polytechnic University
contact email	20033221r@connect.polyu.hk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD058362
     1. Label: PRIDE project
     2. Name: Wild-type KRAS activation drives evasion of interferon-mediated immunity and resistance to immunotherapy in hepatocellular carcinoma